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Spi1tm2.1Dgt
Targeted Allele Detail
Summary
Symbol: Spi1tm2.1Dgt
Name: Spi-1 proto-oncogene; targeted mutation 2.1, Daniel G Tenen
MGI ID: MGI:3688440
Synonyms: PU.1-
Gene: Spi1  Location: Chr2:90912750-90946104 bp, + strand  Genetic Position: Chr2, 50.44 cM, cytoband E3
Alliance: Spi1tm2.1Dgt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114150
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is a derivative of Spfi1tm2Dgt in which the sequences flanked by loxP sites in introns 3 and 5 were deleted by Cre-mediated recombination in ES cells prior to the production of chimeric mice. (J:114150)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spi1 Mutation:  27 strains or lines available
References
Original:  J:114150 Iwasaki H, et al., Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood. 2005 Sep 1;106(5):1590-600
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory