Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabbr1tm3Bet
Name:	gamma-aminobutyric acid type B receptor subunit 1; targeted mutation 3, Bernhard Bettler
MGI ID:	MGI:3665432
Synonyms:	1a-, GABAB(1a)-, GABAB1a-, GB1a-
Gene:	Gabbr1  Location: Chr17:37356888-37385197 bp, + strand  Genetic Position: Chr17, 19.16 cM
Alliance:	Gabbr1tm3Bet page

Germline Transmission:	Earliest citation of germline transmission: J:113340
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	BALB/c

Allele Type:    Targeted (Modified isoform(s)) Mutation:    Nucleotide substitutions   Mutation details: The start codon for the B1a isoform of Gabbr1 was converted into a stop codon to prevent translation of the B1a isoform. A putative alternative start site was also mutated and a floxed neomycin cassette was inserted in the introns between exons 2a and 3a. The neomycin cassette was removed by crossing with mice expressing Cre-recombinase under the control of the cytomegalus virus promoter. Northern blot analysis confirmed absence of the B1a isoform. (J:113340)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabbr1 Mutation:	71 strains or lines available

Original:	J:113340 Vigot R, et al., Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron. 2006 May 18;50(4):589-601
All:	18 reference(s)