Lrp5tm1Lex
Targeted Allele Detail
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Symbol: |
Lrp5tm1Lex |
Name: |
low density lipoprotein receptor-related protein 5; targeted mutation 1, Lexicon Genetics |
MGI ID: |
MGI:3663738 |
Synonyms: |
Lrp5-, Lrp5deltaexon1 |
Gene: |
Lrp5 Location: Chr19:3634828-3736564 bp, - strand Genetic Position: Chr19, 3.33 cM, cytoband B
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Alliance: |
Lrp5tm1Lex page
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Germline Transmission: |
Earliest citation of germline transmission:
J:111359
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Project Collection: |
Lexicon
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A targeting vector was designed to inactivate the locus by inserting an IRES-betagal-MC1-neo into exon 1. Expression of the betagal would have been under the control of the endogenous promoter, however, no expression was detected. RT-PCR failed to detect wild-type transcripts resulting from exon 1. Protein analysis failed to detect immunoreactivity in mutants.
(J:111359)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lrp5 Mutation: |
81 strains or lines available
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Original: |
J:111359 Holmen SL, et al., Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res. 2004 Dec;19(12):2033-40 |
All: |
10 reference(s) |
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