Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ncam2tm1Mom
Name:	neural cell adhesion molecule 2; targeted mutation 1, Peter Mombaerts
MGI ID:	MGI:3663377
Synonyms:	OCAM-exon4-inversion
Gene:	Ncam2  Location: Chr16:80997585-81423716 bp, + strand  Genetic Position: Chr16, 45.89 cM, cytoband C1-3
Alliance:	Ncam2tm1Mom page

Germline Transmission:	Earliest citation of germline transmission: J:111928
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Inversion   Ncam2tm1Mom involves 1 genes/genome features (Ncam2) View all   Mutation details: A targeting vector was designed to insert loxP sites flanking exon 4 and an frt-flanked neo cassette such that expression of cre recombinase in the germline resulted in the inversion of the sequence. The mutant allele expresses mRNA containing an inversion of exon 4. Western blot failed to detect protein in mutant brains. (J:111928)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncam2 Mutation:	87 strains or lines available

Original:	J:111928 Walz A, et al., Disrupted compartmental organization of axons and dendrites within olfactory glomeruli of mice deficient in the olfactory cell adhesion molecule, OCAM. Mol Cell Neurosci. 2006 May-Jun;32(1-2):1-14
All:	2 reference(s)