Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Abcc1tm1Bor
Name:	ATP-binding cassette, sub-family C member 1; targeted mutation 1, Piet Borst
MGI ID:	MGI:2155908
Synonyms:	mrp-, mrp1-, MRP1-
Gene:	Abcc1  Location: Chr16:14179317-14292743 bp, + strand  Genetic Position: Chr16, 9.75 cM
Alliance:	Abcc1tm1Bor page

Germline Transmission:	Earliest citation of germline transmission: J:44110
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A hygromycin selection cassette replaced sequences encoding the first ATP binding domain. No full length or truncated protein was detected in western blots on extracts derived from a variety of tissues from homozygous mice. (J:44110)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc1 Mutation:	75 strains or lines available

Original:	J:44110 Wijnholds J, et al., Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med. 1997 Nov;3(11):1275-9
All:	24 reference(s)