Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ascl2tm1.1Nagy
Name:	achaete-scute family bHLH transcription factor 2; targeted mutation 1.1, Andras Nagy
MGI ID:	MGI:2155757
Synonyms:	Ascl2-lacZ, Mash2-lacZ
Gene:	Ascl2  Location: Chr7:142520566-142523001 bp, - strand  Genetic Position: Chr7, 88.08 cM
Alliance:	Ascl2tm1.1Nagy page

Germline Transmission:	Earliest citation of germline transmission: J:57828
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: This allele is a derivative of Ascl2tm1Nagy in which the loxP flanked neomycin resistance cassette was removed in the germ line via Cre mediated recombination by crossing Ascl2tm1Nagy mice with transgenic mice expressing Cre under the control of the CMV promoter. This allele expressed beta-galactosidase under the control of the endogenous gene promoter. (J:57828)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

35 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ascl2 Mutation:	15 strains or lines available

Original:	J:57828 Tanaka M, et al., Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation. Mech Dev. 1999 Sep;87(1-2):129-42
All:	4 reference(s)