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Slc45a2uw-4J
Chemically induced Allele Detail
Nomenclature
Symbol: Slc45a2uw-4J
Name: solute carrier family 45, member 2; underwhite 4 Jackson
MGI ID: MGI:3656016
Gene: Slc45a2  Location: Chr15:11000721-11029233 bp, + strand  Genetic Position: Chr15, 5.4 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsSequencing of all exons of the gene identified a A T-to-C transition in exon 2 that results in substitution of serine (TCT) for phenylalanine (TTT) in this very highly evolutionarily conserved protein. Failure to complement another mutation at this locus, underwhite 5 Jackson, verified responsibility of these mutations for the observed phenotype. (J:112289)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc45a2 Mutation:  42 strains or lines available
References
Original:  J:112289 Gwynn B, et al., ENU induced mutation in Slc45a2 (underwhite) reduces coat color pigmentation. MGI Direct Data Submission. 2006;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory