Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Slc6a3tm1Hhg
Name:	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Howard H Gu
MGI ID:	MGI:3653596
Synonyms:	DAT-CI
Gene:	Slc6a3  Location: Chr13:73684866-73726791 bp, + strand  Genetic Position: Chr13, 40.1 cM
Alliance:	Slc6a3tm1Hhg page

Germline Transmission:	Earliest citation of germline transmission: J:111041
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Hypomorph, Modified isoform(s)) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A loxP-flanked neo was inserted into intron 3 with the L104V, F105C, and A109V mutations. The neo was subsequently removed from the locus. (J:111041)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:	66 strains or lines available

Original:	J:111041 Chen R, et al., Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9333-8
All:	9 reference(s)