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Ltatm1.1Sned
Targeted Allele Detail
Summary
Symbol: Ltatm1.1Sned
Name: lymphotoxin A; targeted mutation 1.1, Sergei A Nedospasov
MGI ID: MGI:3652393
Synonyms: Ltadelta
Gene: Lta  Location: Chr17:35422141-35424327 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance: Ltatm1.1Sned page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109621
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe entire locus was removed via homologous recombination. Flow cytometry confirmed absence of Lt surface expression. (J:109621)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lta Mutation:  17 strains or lines available
References
Original:  J:109621 Liepinsh DJ, et al., Novel lymphotoxin alpha (LTalpha) knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions. Mol Cell Biol. 2006 Jun;26(11):4214-25
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory