Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cnbpm1Hrb
Name:	cellular nucleic acid binding protein; mutation 1, Klaus Harbers
MGI ID:	MGI:3640662
Synonyms:	A8
Gene:	Cnbp  Location: Chr6:87819597-87828088 bp, - strand  Genetic Position: Chr6, 39.13 cM, cytoband D1-D2
Alliance:	Cnbpm1Hrb page

Germline Transmission:	Earliest citation of germline transmission: J:81582
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Transgene Type:    Transgenic Mutation:    Viral insertion   Mutation details: J1 ES cells were infected with mp10 virus carrying a neomycin resistance gene. After selection, resistant ES cell colonies were analyzed for the presence of single-copy proviral DNA. A mouse line established from one of these cell lines was shown to have an insertion in exon 1 of the Cnbp gene. Northern blots demonstrate that transcript levels are significantly reduced in heterozygous embryos and absent in homozygotes. (J:81582)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cnbp Mutation:	29 strains or lines available

Original:	J:36254 Harbers K, et al., Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12412-7
All:	3 reference(s)