Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ednrbtm1Myks
Name:	endothelin receptor type B; targeted mutation 1, Myung K Shin
MGI ID:	MGI:3640402
Synonyms:	EdnrblacZ
Gene:	Ednrb  Location: Chr14:104052061-104081838 bp, - strand  Genetic Position: Chr14, 53.05 cM
Alliance:	Ednrbtm1Myks page

Germline Transmission:	Earliest citation of germline transmission: J:84057
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to insert a LacZ into exon 1 immediately downstream of the ATG, replacing sequence encoding the extracellular domain and the first two transmembrane spanning domains. Cre mediated excision removed a floxed neo. (J:84057)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	127 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ednrb Mutation:	103 strains or lines available

Original:	J:84057 Lee HO, et al., The endothelin receptor-B is required for the migration of neural crest-derived melanocyte and enteric neuron precursors. Dev Biol. 2003 Jul 1;259(1):162-75
All:	4 reference(s)