Myctm1Dmlo
Targeted Allele Detail
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| Symbol: |
Myctm1Dmlo |
| Name: |
myelocytomatosis oncogene; targeted mutation 1, Dominique Morello |
| MGI ID: |
MGI:3640382 |
| Synonyms: |
Myc*neo3'SV |
| Gene: |
Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
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| Alliance: |
Myctm1Dmlo page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:70610
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| Parent Cell Line: |
CK35 (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Allele Type: |
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Targeted (Conditional ready, Humanized sequence) |
| Mutation: |
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Insertion
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Mutation details: A targeting vector was designed to contain a 159-nt long human MYC sequence encoding the carboxy terminal part of the protein for insertion in place of the corresponding mouse sequence. The vector contained a neomycin resistance cassette with an RNA polymerase II promoter but without a polyA sequence immediately downstream of the MYC stop codon. The 3' UTR of the endogenous myc, including runs of Us, AREs and the two polyA sites was deleted and replaced by late SV40 3' UTR including a polyA site.
(J:70610)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Myc Mutation: |
42 strains or lines available
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| Original: |
J:70610 Langa F, et al., Healthy mice with an altered c-myc gene: role of the 3' untranslated region revisited. Oncogene. 2001 Jul 19;20(32):4344-53 |
| All: |
1 reference(s) |
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Analysis Tools
