Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gnmttm1Cwa
Name:	glycine N-methyltransferase; targeted mutation 1, Conrad Wagner
MGI ID:	MGI:3640328
Gene:	Gnmt  Location: Chr17:47036590-47040091 bp, - strand  Genetic Position: Chr17, 22.9 cM, cytoband C
Alliance:	Gnmttm1Cwa page

Germline Transmission:	Earliest citation of germline transmission: J:110257
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first exon and promoter region were replaced with a neomycin resistance gene via homologous recombination. Western blot and enzyme activity assays did not detect any protein or activity in homozygous liver extracts. (J:110257)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gnmt Mutation:	23 strains or lines available

Original:	J:110257 Luka Z, et al., A Glycine N-methyltransferase Knockout Mouse Model for Humans with Deficiency of this Enzyme. Transgenic Res. 2006 Jun;15(3):393-7
All:	8 reference(s)