Summary | Transgene origin | Transgene description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(H2-K-Fosl1)1Wag
Name:	transgene insertion 1, Erwin F Wagner
MGI ID:	MGI:3639512
Synonyms:	fra-1tg, Fra1 Tg
Transgene:	Tg(H2-K-Fosl1)1Wag  Location: unknown
Alliance:	Tg(H2-K-Fosl1)1Wag page

Strain of Origin:

(C57BL/6 x CBA)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(H2-K-Fosl1)1Wag expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Fosl1 (MGI:107179)   Mutation details: This transgene contains the murine Fosl1 gene fused to the major histocompatibility complex class I antigen H2-Kb promoter. To stabilize the Fosl1 mRNA and ensure expression in mesenchymal cells, the 3' long terminal repeat sequence of the FBJ-murine sarcoma virus was linked to the 3' end of the Fosl1 gene. Fosl1 mRNA is widely expressed in various organs, including bone. (J:64494)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:64494 Jochum W, et al., Increased bone formation and osteosclerosis in mice overexpressing the transcription factor fra-1. Nat Med. 2000 Sep;6(9):980-4
All:	9 reference(s)