Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fgf10Tg(Myl3-lacZ)24Buck
Name:	fibroblast growth factor 10; transgene insertion 24, Margaret E Buckingham
MGI ID:	MGI:3629660
Synonyms:	Fgf10-, Fgf10lacZ, Fgf10Mlc1v-nLacZ-v24, Fgf10mlcv, Fgf10Mlcv-nlacZ-v24, Mlc1v-nlacZ-24
Gene:	Fgf10  Location: Chr13:118851199-118928651 bp, + strand  Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
Alliance:	Fgf10Tg(Myl3-lacZ)24Buck page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Hypomorph, Reporter) Mutation:    Insertion   Mutation details: The transgene contains 757 bp upstream of the transcriptional start site, the 5' UTR and the first 33 codons of the mouse myosin light polypeptide 3 gene upstream of nlacZ. The promoter contains a 34 bp deletion at -150 relative to the transcription start site. Two to three copies of the transgene integrated 114 kb upstream of the locus in a head-to-tail array. Expression of the transgene is in a highly similar pattern to that of Fgf10 in the embryo. Whole mount in-situ analysis detected decreased expression of the endogenous gene in homozygous embryos indicating this is a hypomorphic allele. (J:71788, J:98521)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf10 Mutation:	33 strains or lines available

Original:	J:71788 Kelly RG, et al., The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev Cell. 2001 Sep;1(3):435-440
All:	44 reference(s)