Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tnftm2.1Gkl
Name:	tumor necrosis factor; targeted mutation 2.1, George Kollias
MGI ID:	MGI:3625620
Synonyms:	TnfdeltaAREneo
Gene:	Tnf  Location: Chr17:35418357-35420983 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance:	Tnftm2.1Gkl page

Germline Transmission:	Earliest citation of germline transmission: J:54056
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: This allele was the predecessor for Tnftm2Gkl. A floxed neo cassette was inserted into the locus, replacing the 69 bp encompassing the AU-rich elements (ARE) by homologous recombination. (J:54056)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:	46 strains or lines available

Original:	J:54056 Kontoyiannis D, et al., Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies. Immunity. 1999 Mar;10(3):387-98
All:	4 reference(s)