Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grik2tm1Bvis
Name:	glutamate receptor, ionotropic, kainate 2 (beta 2); targeted mutation 1, B Vissel
MGI ID:	MGI:3623590
Synonyms:	ECSdelta
Gene:	Grik2  Location: Chr10:48970929-49664862 bp, - strand  Genetic Position: Chr10, 24.87 cM
Alliance:	Grik2tm1Bvis page

Germline Transmission:	Earliest citation of germline transmission: J:107698
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to remove the editing complementary site by replacement with a floxed neomysin resistance gene, and subsequent removal of that gene. An editing assay confirmed that editing was essentially abolished in mutant mice. (J:107698)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grik2 Mutation:	64 strains or lines available

Original:	J:107698 Vissel B, et al., The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron. 2001 Jan;29(1):217-27
All:	4 reference(s)