Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nod2tm1Vmd
Name:	nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Vishva M Dixit
MGI ID:	MGI:3622092
Synonyms:	Nod2-
Gene:	Nod2  Location: Chr8:89373943-89415102 bp, + strand  Genetic Position: Chr8, 43.51 cM, cytoband C3
Alliance:	Nod2tm1Vmd page

Germline Transmission:	Earliest citation of germline transmission: J:106976
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was replaced with a PGK-neomycin resistance cassette. Stop codons in all 3 reading frames were introduced after the exon 3 splice acceptor site. Western blot failed to detect protein in mutants. (J:106976)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nod2 Mutation:	62 strains or lines available

Original:	J:106976 Mariathasan S, et al., Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006 Mar 9;440(7081):228-32
All:	2 reference(s)