Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lmnatm2Lgf
Name:	lamin A; targeted mutation 2, Loren G Fong
MGI ID:	MGI:3620627
Synonyms:	LmnaLCO
Gene:	Lmna  Location: Chr3:88388455-88413842 bp, - strand  Genetic Position: Chr3, 38.84 cM
Alliance:	Lmnatm2Lgf page

Germline Transmission:	Earliest citation of germline transmission: J:106473
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to delete the last 150 nucleotides of exon 11 and all of intron 11. The deletion created an in-frame fusion between codon 608 in exon 11 and codon 659 in exon 12. A floxed neo included in the vector was removed via cre-mediated recombination. Northern and Western blot demonstrated that no lamin A was produced. Lamin C was produced at wild-type levels. (J:106473)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmna Mutation:	82 strains or lines available

Original:	J:106473 Fong LG, et al., Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest. 2006 Mar;116(3):743-52
All:	5 reference(s)