Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Cdc42tm1Brak Name: cell division cycle 42; targeted mutation 1, Cord Brakebusch MGI ID: MGI:3619134 Synonyms: Cdc42fl, Cdc42flox Gene: Cdc42  Location: Chr4:137047007-137085031 bp, - strand  Genetic Position: Chr4, 69.83 cM Alliance: Cdc42tm1Brak page

Kidney abnormalities in Cdc42tm1Brak/Cdc42tm1Brak Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:105811
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion     Exon 2 was flanked with loxP sites via homologous recombination. (J:105811)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	126 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

List all tumor models in MMHCdb carrying Cdc42tm1Brak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc42 Mutation:	43 strains or lines available

Original:	J:105811 Wu X, et al., Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev. 2006 Mar 1;20(5):571-85
All:	51 reference(s)