Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prnptm1Canc
Name:	prion protein; targeted mutation 1, Enrico Cancellotti
MGI ID:	MGI:3619122
Synonyms:	G1
Gene:	Prnp  Location: Chr2:131751848-131780349 bp, + strand  Genetic Position: Chr2, 64.07 cM
Alliance:	Prnptm1Canc page

Germline Transmission:	Earliest citation of germline transmission: J:105909
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted Mutation:    Insertion   Mutation details: Homologous recombination was used to insert a N180T mutation into exon 3 in order to eliminate the first glycosylation site. Northern blot demonstrated presence of the mutation does not interfere with transcription. (J:105909)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:	150 strains or lines available

Original:	J:105909 Cancellotti E, et al., Altered glycosylated PrP proteins can have different neuronal trafficking in brain but do not acquire scrapie-like properties. J Biol Chem. 2005 Dec 30;280(52):42909-18
All:	3 reference(s)