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Chemically induced Allele Detail
Symbol: Stat1m1Btlr
Name: signal transducer and activator of transcription 1; mutation 1, Bruce Beutler
MGI ID: MGI:3619019
Synonyms: Dom, Domino, Stat1Dom
Gene: Stat1  Location: Chr1:52119440-52161865 bp, + strand  Genetic Position: Chr1, 26.81 cM
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThis mutation was identified in a screen of progeny of ENU-mutagenized mice for response to cytomegalovirus infection. It comprises a T-to-A transversion in exon 11 that results in replacement of valine by glutamic acid at amino acid position 319 (V319E), at the beginning of the DNA binding domain of the protein. Western blot analysis of macrophage protein detects low levels of STAT1. The protein fails to undergo normal phosphorylation of serine 727 or tyrosine 701 upon interferon treatment. (J:88776, J:105543)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stat1 Mutation:  24 strains or lines available
Mice carrying ENU mutations in this marker show higher susceptibility to mouse cytomegalovirus than that observed in susceptible BALB/c mice.
Original:  J:105543 Crozat K, et al., Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome. 2006 May;17(5):398-406
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory