Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(DTA)Mrc
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Mario R Capecchi
MGI ID:	MGI:3618991
Synonyms:	R26RDTA, ROSA26-DTA176, ROSADTA
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(DTA)Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:105927
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change) Mutation:    Insertion   Mutation details: The DTA176 coding sequence was targeted into the Rosa26 locus but remains unexpressed until a loxP flanked stop sequence is removed via cre-mediated recombination. (J:105927)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

15 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:105927 Wu S, et al., Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo. Development. 2006 Feb;133(4):581-90
All:	81 reference(s)