Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	GckSgrd-2Nwu
Name:	glucokinase; sugar daddy 2 Northwestern University
MGI ID:	MGI:3618627
Synonyms:	GCKP417R
Gene:	Gck  Location: Chr11:5850820-5900081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Alliance:	GckSgrd-2Nwu page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: ENU mutagenesis induced a C to G substitution that results in the amino acid substitution of arginine for proline at position 417(P417R). Western blot analysis confirmed normal protein expression in the liver. (J:196563) Inheritance:    Semidominant

Location of the ENU GckSgrd-2Nwu mutation

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gck Mutation:	59 strains or lines available

Original:	J:196563 Fenner D, et al., Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators. J Biol Chem. 2011 Nov 11;286(45):39560-72
All:	1 reference(s)