Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pex5tm1Baes
Name:	peroxisomal biogenesis factor 5; targeted mutation 1, Myriam Baes
MGI ID:	MGI:2154454
Synonyms:	Pex5-
Gene:	Pex5  Location: Chr6:124373775-124392026 bp, - strand  Genetic Position: Chr6, 59.15 cM
Alliance:	Pex5tm1Baes page

Germline Transmission:	Earliest citation of germline transmission: J:42719
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Four exons encoding most of the tetratricopeptide repeats were replaced by a neo cassette. The absence of transcript was confirmed by Northern analysis and RT-PCR. By Western analysis, neither the 70kDa protein nor truncated forms were detectable from liver extracts. (J:42719)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pex5 Mutation:	29 strains or lines available

Original:	J:42719 Baes M, et al., A mouse model for Zellweger syndrome. Nat Genet. 1997 Sep;17(1):49-57
All:	11 reference(s)