Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chrngtm1(Chrne)Mknn
Name:	cholinergic receptor, nicotinic, gamma polypeptide; targeted mutation 1, Michael Koenen
MGI ID:	MGI:3615397
Synonyms:	AChRgammaepsilon
Gene:	Chrng  Location: Chr1:87133533-87139365 bp, + strand  Genetic Position: Chr1, 44.07 cM
Alliance:	Chrngtm1(Chrne)Mknn page

Germline Transmission:	Earliest citation of germline transmission: J:105142
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a sequence containing the N-terminal 133 amino acids of Chrng fused to 382 amino acids of Chrne, including transmembrane segments 1-4. Mutants lacked endogenous transcripts at birth, however, mutant transcript levels matched levels of other cholinergic receptor subunits. Mutant transcript levels then decreased during postnatal development, as expected for regulatory sequences in the endogenous locus. (J:105142)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrng Mutation:	29 strains or lines available

Original:	J:105142 Koenen M, et al., Acetylcholine receptor channel subtype directs the innervation pattern of skeletal muscle. EMBO Rep. 2005 Jun;6(6):570-6
All:	1 reference(s)