Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Arhgdiatm1Ytk
Name:	Rho GDP dissociation inhibitor alpha; targeted mutation 1, Yoshimi Takai
MGI ID:	MGI:3613573
Synonyms:	Rho GDIalpha -
Gene:	Arhgdia  Location: Chr11:120468930-120472450 bp, - strand  Genetic Position: Chr11, 84.29 cM
Alliance:	Arhgdiatm1Ytk page

Germline Transmission:	Earliest citation of germline transmission: J:57995
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3kb MC1-neomycin resistance cassette replaced all three exons. Western blot analysis did not detect protein in spleen lysates from homozygous mutant mice. (J:57995)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgdia Mutation:	18 strains or lines available

Original:	J:57995 Togawa A, et al., Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Oncogene. 1999 Sep 23;18(39):5373-80
All:	5 reference(s)