Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gli3Pdn
Name:	GLI-Kruppel family member GLI3; polydactyly Nagoya
MGI ID:	MGI:1856282
Synonyms:	Pdn
Gene:	Gli3  Location: Chr13:15638308-15904611 bp, + strand  Genetic Position: Chr13, 5.43 cM, cytoband A2
Alliance:	Gli3Pdn page

Strain of Origin:

Jcl:ICR

Allele Type:    Spontaneous (Hypomorph) Mutation:    Transposon insertion   Mutation details: This hypomorphic allele was shown to contain a 5442 bp early retrotransponson in intron 3 by PCR analysis. The transposon was similar to a known retrotransposon, MMY17106, containing 317 bp long terminal repeats followed by 6 bp target duplication sequences at each end. RT-PCR analysis of homozygous mutant mice has shown several species of aberrant transcripts and indicated that the amount of message present in homozygous mutant mice is approximately 20% of the wild-type level. (J:18650, J:53808, J:82981) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	109 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gli3 Mutation:	80 strains or lines available

Original:	J:12736 Hayasaka I, et al., Polydactyly Nagoya, Pdn: A new mutant gene in the mouse. Jikken Dobutsu. 1980 Oct;29(4):391-5
All:	31 reference(s)