Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Fut8tm1Nta Name: fucosyltransferase 8; targeted mutation 1, Naoyuki Taniguchi MGI ID: MGI:3608699 Synonyms: Fut8- Gene: Fut8  Location: Chr12:77284899-77523112 bp, + strand  Genetic Position: Chr12, 35.46 cM Alliance: Fut8tm1Nta page

Growth retardation in Fut8tm1Nta/Fut8tm1Nta mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:102932
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2, which contains the translation initiation site, was replaced with an IRES-LacZ-Neo-pA cassette. Northern blot analysis of lung and brain RNA confirmed absence of full-length mRNA. (J:102932)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fut8 Mutation:	37 strains or lines available

Original:	J:102932 Wang X, et al., Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15791-6
All:	23 reference(s)