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Ext2tm1Werb
Targeted Allele Detail
Summary
Symbol: Ext2tm1Werb
Name: exostosin glycosyltransferase 2; targeted mutation 1, Zena Werb
MGI ID: MGI:3608690
Gene: Ext2  Location: Chr2:93525978-93652913 bp, - strand  Genetic Position: Chr2, 51.62 cM
Alliance: Ext2tm1Werb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103125
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced by a PGK-neo cassette via homologous recombination. RT-PCR and western blot analysis detected a truncated RNA and protein product in trophoblast stem cells, however heparan sulfate synthesis does not occur. (J:103125)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ext2 Mutation:  41 strains or lines available
References
Original:  J:103125 Stickens D, et al., Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development. 2005 Nov;132(22):5055-68
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory