Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rettm5(RET)Vpa
Name:	ret proto-oncogene; targeted mutation 5, Vassilis Pachnis
MGI ID:	MGI:3607931
Synonyms:	Ret951-RI
Gene:	Ret  Location: Chr6:118128706-118174679 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance:	Rettm5(RET)Vpa page

Germline Transmission:	Earliest citation of germline transmission: J:102170
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Mutation details: A cDNA fragment encoding the intracellular portion of the human RET9 isoform was fused in-frame with mouse exon 11 immediately downstream of the transmembrane domain-coding region. The inserted cDNA contained substitutions changing the amino acids M and S at the start of the Ret51 specific sequence to R and I, and was followed by a floxed PGK-neo cassette. (J:102170)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:	53 strains or lines available

Original:	J:102170 Wong A, et al., Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform. Mol Cell Biol. 2005 Nov;25(21):9661-73
All:	1 reference(s)