Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grm6nob3
Name:	glutamate receptor, metabotropic 6; no b wave 3
MGI ID:	MGI:3605835
Gene:	Grm6  Location: Chr11:50741512-50757035 bp, + strand  Genetic Position: Chr11, 30.93 cM
Alliance:	Grm6nob3 page

Strain of Origin:

C57BL/10

Allele Type:    Spontaneous (Null/knockout) Mutation:    Single point mutation   Mutation details: A C-to-T transition occured spontaneously in intron 1. This results in a new splice donor site (G-GT from G-GC), which alters splicing and, together with an upstream cryptic splice donor CAG, inserts a new 65 bp exon between exons 1 and 2. This leads to a frame shift and premature termination. The absence of protein expression was confirmed by immunohistochemistry on the outer plexiform layer. (J:152828)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grm6 Mutation:	51 strains or lines available

Original:	J:152828 Maddox DM, et al., Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses. J Physiol. 2008 Sep 15;586(Pt 18):4409-24
All:	15 reference(s)