Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Npm1tm1Ppp
Name:	nucleophosmin 1; targeted mutation 1, Pier Paolo Pandolfi
MGI ID:	MGI:3604807
Synonyms:	Npm-
Gene:	Npm1  Location: Chr11:33102287-33113206 bp, - strand  Genetic Position: Chr11, 19.21 cM
Alliance:	Npm1tm1Ppp page

Germline Transmission:	Earliest citation of germline transmission: J:101494
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector containing GFP was inserted in-frame with exon 2 at the upstream end, with a modified ACN cassette containing a self-excising neo, resulting in the removal of exons 2-7. GFP was demonstrated to express in the same manner as the endogenous protein. (J:101494)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

List all tumor models in MMHCdb carrying Npm1tm1Ppp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npm1 Mutation:	33 strains or lines available

Original:	J:101494 Grisendi S, et al., Role of nucleophosmin in embryonic development and tumorigenesis. Nature. 2005 Sep 1;437(7055):147-53
All:	4 reference(s)