Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Itpr2tm1Kmik
Name:	inositol 1,4,5-triphosphate receptor 2; targeted mutation 1, Katsuhiko Mikoshiba
MGI ID:	MGI:3604623
Synonyms:	IP3R2-
Gene:	Itpr2  Location: Chr6:146009797-146403721 bp, - strand  Genetic Position: Chr6, 77.7 cM
Alliance:	Itpr2tm1Kmik page

Germline Transmission:	Earliest citation of germline transmission: J:101380
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The first exon coding the first six amino acids was fused in-frame to the lacZ gene with an NLS. Immunoblot failed to detect protein in mutants. (J:101380)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Itpr2 Mutation:	147 strains or lines available

Original:	J:101380 Futatsugi A, et al., IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science. 2005 Sep 30;309(5744):2232-4
All:	23 reference(s)