Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Cxcr3tm1Dgen
Name:	C-X-C motif chemokine receptor 3; targeted mutation 1, Deltagen
MGI ID:	MGI:3604545
Gene:	Cxcr3  Location: ChrX:100775141-100777753 bp, - strand  Genetic Position: ChrX, 44.58 cM
Alliance:	Cxcr3tm1Dgen page

Mutant Cell Line:	2697
Germline Transmission:	Earliest citation of germline transmission: J:101679
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in spleen, lymph nodes and ovary, moderate levels in cerebellum, lung, liver, pancreas, kidney, thymus, bone marrow, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, colon, epididymis, seminal vesicle, coagulating gland, uterus and white fat, and low levels in whole brain, cortex, subcortical region, brainstem, olfactory bulb, spinal cord, eye, Harderian glands, heart, skeletal muscle, tongue, stomach, small intestine, cecum, testis and prostate gland. However, faint beta-galactosidase expression from this allele is detectable in only in whole mount brain.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	51 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcr3 Mutation:	10 strains or lines available

Original:	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:	75 reference(s)