Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Adamts4tm1Dgen
Name:	ADAM metallopeptidase with thrombospondin type 1 motif 4; targeted mutation 1, Deltagen
MGI ID:	MGI:3604481
Gene:	Adamts4  Location: Chr1:171077990-171088206 bp, + strand  Genetic Position: Chr1, 79.28 cM
Alliance:	Adamts4tm1Dgen page

Mutant Cell Line:	3733
Germline Transmission:	Earliest citation of germline transmission: J:101679
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. The highest levels of RNA transcripts are detectable in whole brain, cortex, subcortical region, cerebellum, brainstem, olfactory bulb, spinal cord, ovary and uterus. Moderate levels of RNA transcripts are detectable in eye, Harderian glands, lung, pancreas, kidney, spleen, thymus, lymph nodes, bone marrow, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, cecum, colon, testis, epididymis, seminal vesicle, coagulating gland, prostate gland, and white fat. Lower levels of RNA transcripts are also detectable in heart. LacZ (beta-galactosidase) expression is detectable in brain, spinal cord, eyes, bone marrow, tongue, skin, ear, male and female reproductive systems.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

75 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adamts4 Mutation:	48 strains or lines available

Original:	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:	11 reference(s)