Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grm1tm1Kyo
Name:	glutamate receptor, metabotropic 1; targeted mutation 1, Tadao Serikawa
MGI ID:	MGI:3604007
Synonyms:	Grm1tm1Nak, mGluR1 D854T
Gene:	Grm1  Location: Chr10:10561803-10958100 bp, - strand  Genetic Position: Chr10, 3.44 cM, cytoband A2
Alliance:	Grm1tm1Kyo page

Germline Transmission:	Earliest citation of germline transmission: J:101301
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The D854T mutation was inserted into the exon encoding the 7 transmembrane domain. Transient expression of cre recombinase removed a floxed neo included in the targeting vector. Expression of RNA in mutant cerebellum was similar to wild-type. Protein expression in mutants was normal. (J:101301)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Grm1 Mutation:	78 strains or lines available

Original:	J:101301 Sato M, et al., Altered agonist sensitivity and desensitization of neuronal mGluR1 responses in knock-in mice by a single amino acid substitution at the PKC phosphorylation site. Eur J Neurosci. 2004 Aug;20(4):947-55
All:	1 reference(s)