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Smarcb1tm1Gvk
Targeted Allele Detail
Summary
Symbol: Smarcb1tm1Gvk
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; targeted mutation 1, Ganjam V Kalpana
MGI ID: MGI:3603561
Synonyms: Ini1delta6,7
Gene: Smarcb1  Location: Chr10:75732603-75757448 bp, - strand  Genetic Position: Chr10, 38.61 cM
Alliance: Smarcb1tm1Gvk page
Smarcb1tm1Gvk/Smarcb1+ mice develop tumors that overexpress Cyclin D1

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101185
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6 and 7 were replaced with a PGK-hygromycin resistance cassette. Immunoblot of total protein from heterozygous mice failed to detect a truncated protein corresponding to the mutant allele, thereby indicating it is most likely a null. (J:101185)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smarcb1 Mutation:  22 strains or lines available
References
Original:  J:101185 Tsikitis M, et al., Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12129-34
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory