Smarcb1tm1Gvk
Targeted Allele Detail
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Symbol: |
Smarcb1tm1Gvk |
Name: |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; targeted mutation 1, Ganjam V Kalpana |
MGI ID: |
MGI:3603561 |
Synonyms: |
Ini1delta6,7 |
Gene: |
Smarcb1 Location: Chr10:75732603-75757448 bp, - strand Genetic Position: Chr10, 38.61 cM
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Alliance: |
Smarcb1tm1Gvk page
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Smarcb1tm1Gvk/Smarcb1+ mice develop tumors that overexpress Cyclin D1
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:101185
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Parent Cell Line: |
WW6 (ES Cell)
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Strain of Origin: |
STOCK 129/Sv and C57BL/6J and SJL
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 6 and 7 were replaced with a PGK-hygromycin resistance cassette. Immunoblot of total protein from heterozygous mice failed to detect a truncated protein corresponding to the mutant allele, thereby indicating it is most likely a null.
(J:101185)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Smarcb1 Mutation: |
22 strains or lines available
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Original: |
J:101185 Tsikitis M, et al., Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12129-34 |
All: |
2 reference(s) |
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