Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mus81tm1Chmg
Name:	MUS81 structure-specific endonuclease subunit; targeted mutation 1, Clare H McGowan
MGI ID:	MGI:3588581
Synonyms:	Mus81-
Gene:	Mus81  Location: Chr19:5532589-5538461 bp, - strand  Genetic Position: Chr19, 4.34 cM
Alliance:	Mus81tm1Chmg page

Germline Transmission:	Earliest citation of germline transmission: J:100407
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion     Cre mediated excision was used to remove exons 9-12, which includes the endonuclease domain. (J:100407)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mus81 Mutation:	29 strains or lines available

Original:	J:100407 Dendouga N, et al., Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol. 2005 Sep;25(17):7569-79
All:	6 reference(s)