Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atg7tm1.1Tchi
Name:	autophagy related 7; targeted mutation 1.1, Tomoki Chiba
MGI ID:	MGI:3587771
Synonyms:	Atg7-
Gene:	Atg7  Location: Chr6:114620075-114837565 bp, + strand  Genetic Position: Chr6, 53.05 cM, cytoband E3
Alliance:	Atg7tm1.1Tchi page

Germline Transmission:	Earliest citation of germline transmission: J:100199
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Crossing Atg7tm1Tchi with mice expressing cre recombinase in oocytes resulted in the loss of exon 14. Neither transcript nor protein was detected in mutants. Loss of activity was also detected in neonate livers by examining the ATG conjugation systems. (J:100199)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atg7 Mutation:	51 strains or lines available

Original:	J:100199 Komatsu M, et al., Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005 May 9;169(3):425-34
All:	36 reference(s)