Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mbptm1Atc
Name:	myelin basic protein; targeted mutation 1, Anthony T Campagnoni
MGI ID:	MGI:3586965
Synonyms:	golli-
Gene:	Mbp  Location: Chr18:82493271-82603762 bp, + strand  Genetic Position: Chr18, 55.84 cM, cytoband E2-E4
Alliance:	Mbptm1Atc page

Germline Transmission:	Earliest citation of germline transmission: J:100022
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neo marker in reverse orientation replaced exon 2. Western blot of mutant brain, thymocytes and splenocytes confirmed absence of protein. (J:100022)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mbp Mutation:	30 strains or lines available

Original:	J:100022 Jacobs EC, et al., Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene. J Neurosci. 2005 Jul 27;25(30):7004-13
All:	8 reference(s)