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Waptm1Kuw
Targeted Allele Detail
Nomenclature
Symbol: Waptm1Kuw
Name: whey acidic protein; targeted mutation 1, Kay-Uwe Wagner
MGI ID: MGI:3584430
Gene: Wap  Location: Chr11:6635482-6638637 bp, - strand  Genetic Position: Chr11, 4.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100003
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first exon and the splicing signal at the first exon-intron junction have been replaced by a loxP-flanked Pgk-neo cassette. No whey acidic protein mRNA or protein is detectable by northern or western blot analysis, respectively, in the mammary glands or milk on day 1 of lactation of dams homozygous for the targeted allele, nor is the protein detected in their secretory alveoli by immunohistochemical analysis. Expression in heterozygous dams does not differ significantly from that in wild-type mothers. (J:100003)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wap Mutation:  16 strains or lines available
References
Original:  J:100003 Triplett AA, et al., Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells. Genesis. 2005 Aug 16;43(1):1-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory