Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fgfr2tm3Dsn
Name:	fibroblast growth factor receptor 2; targeted mutation 3, Clive Dickson
MGI ID:	MGI:2153818
Synonyms:	FgfR2-IIIb-lacZ
Gene:	Fgfr2  Location: Chr7:129764181-129868538 bp, - strand  Genetic Position: Chr7, 73.19 cM
Alliance:	Fgfr2tm3Dsn page

Germline Transmission:	Earliest citation of germline transmission: J:67731
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified isoform(s), Reporter) Mutation:    Insertion   Mutation details: The IIIb isoform of the gene was specifically disrupted by inserting an IRES-lacZ gene cassette into exon IIIb. An adjacent loxP flanked neomycin cassette was removed via Cre mediated recombination by injecting fertilized heterozygous eggs with an vector expressing Cre recombinase. (J:67731)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	32 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:	87 strains or lines available

Original:	J:67731 Revest JM, et al., Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4. Dev Biol. 2001 Mar 1;231(1):47-62
All:	6 reference(s)