Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hmga1tm1Brun
Name:	high mobility group AT-hook 1; targeted mutation 1, Antonio Brunetti
MGI ID:	MGI:3583805
Synonyms:	Hmga1-
Gene:	Hmga1  Location: Chr17:27775471-27782648 bp, + strand  Genetic Position: Chr17, 14.5 cM
Alliance:	Hmga1tm1Brun page

Germline Transmission:	Earliest citation of germline transmission: J:99652
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3, which contains the start site, and exons 4 and 5, were replaced with a neomycin resistance gene. RT-PCR failed to detect transcript from mutant muscle and fat samples. (J:99652)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmga1 Mutation:	21 strains or lines available

Original:	J:99652 Foti D, et al., Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nat Med. 2005 Jul;11(7):765-73
All:	7 reference(s)