Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Fgfr2tm2Dsn Name: fibroblast growth factor receptor 2; targeted mutation 2, Clive Dickson MGI ID: MGI:2153813 Synonyms: FgfR2-IIIcneo-flox Gene: Fgfr2  Location: Chr7:129764181-129868538 bp, - strand  Genetic Position: Chr7, 73.19 cM Alliance: Fgfr2tm2Dsn page

Submandibular gland is hypoplastic in Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0, Fgf10tm1Wss/Fgf10+, and Fgf10tm1Wss/Fgf10+ Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0 mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:72517
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP flanked neomycin resistance and thymidine kinase cassette was inserted into intron 8 and a single loxP site was inserted into intron 9. (J:72517)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:	87 strains or lines available

Original:	J:72517 Hajihosseini MK, et al., A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3855-60
All:	2 reference(s)