Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bdnftm1Krj
Name:	brain derived neurotrophic factor; targeted mutation 1, Kevin R Jones
MGI ID:	MGI:3582638
Synonyms:	Bdnfklox, BDNFlox, BDNF-loxp, BDNF-LSL-LacZ
Gene:	Bdnf  Location: Chr2:109505045-109557352 bp, + strand  Genetic Position: Chr2, 56.63 cM
Alliance:	Bdnftm1Krj page

Germline Transmission:	Earliest citation of germline transmission: J:84683
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change, Reporter) Mutation:    Insertion   Mutation details: A targeting construct was designed to flank the pro encoding region and mature hormone-encoding region of exon V with loxP sites, with a trimerized polyadenylation signal upstream of the 3' loxP sequence and a lacZ gene and FRT-flanked neomycin resistance cassette downstream of the 3' loxP sequence. Cre mediated excision would enable transcription and translation of lacZ in place of Bdnf. (J:84683)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bdnf Mutation:	39 strains or lines available

Original:	J:84683 Gorski JA, et al., Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci. 2003 Jul 30;23(17):6856-65
All:	29 reference(s)