Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tektm1Ber
Name:	TEK receptor tyrosine kinase; targeted mutation 1, Alan Bernstein
MGI ID:	MGI:3581758
Synonyms:	Tie2F1100
Gene:	Tek  Location: Chr4:94627526-94763213 bp, + strand  Genetic Position: Chr4, 43.34 cM
Alliance:	Tektm1Ber page

Germline Transmission:	Earliest citation of germline transmission: J:99096
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A targeting vector was designed to change tyrosine 1100 to phenylalanine (Y1100F). Flow cytometry of E9.5 embryos demonstrated expression of surface protein was comparable to that in wild-type embryos. (J:99096)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tek Mutation:	92 strains or lines available

Original:	J:99096 Tachibana K, et al., Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis. Mol Cell Biol. 2005 Jun;25(11):4693-702
All:	1 reference(s)