Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Tlx1tm1Thr
Name:	T cell leukemia, homeobox 1; targeted mutation 1, Terence H Rabbitts
MGI ID:	MGI:3581680
Synonyms:	Hox11-, Hox11tm1Rab, Tlx-
Gene:	Tlx1  Location: Chr19:45139119-45145382 bp, + strand  Genetic Position: Chr19, 38.45 cM
Alliance:	Tlx1tm1Thr page

Germline Transmission:	Earliest citation of germline transmission: J:28700
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A lacZ-neo was inserted into exon 1 at codon 50, thereby preventing transcription of codons 51-189 and creating a null allele. (J:28700)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	123 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tlx1 Mutation:	20 strains or lines available

Original:	J:28700 Dear TN, et al., The Hox11 gene is essential for cell survival during spleen development. Development. 1995 Sep;121(9):2909-15
All:	9 reference(s)