Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Runx1tm3(Runx3)Toku
Name:	runt related transcription factor 1; targeted mutation 3, Tsukasa Okuda
MGI ID:	MGI:3581528
Synonyms:	AML1-3
Gene:	Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance:	Runx1tm3(Runx3)Toku page

Germline Transmission:	Earliest citation of germline transmission: J:98965
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: cDNA encoding the C-terminal region of Runx3, the polyA signal and a puromycin resistance cassette were inserted to replace the endogenous C-terminus. RT-PCR demonstrated mRNA levels were comparable to wild-type. (J:98965)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:	35 strains or lines available

Original:	J:98965 Fukushima-Nakase Y, et al., Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development. Blood. 2005 Jun 1;105(11):4298-307
All:	1 reference(s)