Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Krastm1(Hras)Rdl
Name:	Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Roberto Di Lauro
MGI ID:	MGI:3581451
Synonyms:	HrasKI, Kras(Hras)
Gene:	Kras  Location: Chr6:145162425-145195965 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Alliance:	Krastm1(Hras)Rdl page

Germline Transmission:	Earliest citation of germline transmission: J:98940
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout) Mutation:    Insertion   Mutation details: A cassette containing Hras1 cDNA and a neo was fused in-frame with exon 2 such that synthesis of any Kras product would be abolished. Kras protein was undetectable in mutants. Hras1 protein was demonstrated to be present in brain, heart, liver, lung and spinal cord of mutants. (J:98940)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:	76 strains or lines available

Original:	J:98940 Potenza N, et al., Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. EMBO Rep. 2005 May;6(5):432-7
All:	5 reference(s)